The Effects of Ligand Bound Urokinase Plasminogen Activator Receptor on the MAP Kinase Pathway of Cancer Cells
This research focuses on the relationship between the urokinase plasminogen activator receptor system and the mitogen activated protein kinase pathway in prostate cancer cells. Urokinase plasminogen activators are enzymes that convert plasminogen to plasmin that breaks down proteins of the extra cellular matrix. The two ligands for this receptor are single chain and two chain urokinase plasminogen activators. Single chain is found in higher abundance in the blood stream than its counterpart, but two chain has more enzymatic activity than its single chain counterpart.
School:
Morehouse College
Department:
Biology and Music
Research Advisor:
Dr. Naveen Manchanda M.D.
Department of Research Advisor:
Biochemistry
Year of Publication:
2004